1. Origin & Structure

• PDRN (Polydeoxyribonucleotide):

  • A subset of PN, consisting of DNA fragments with a specific molecular weight (100–300 kDa).

  • Extracted mainly from salmon sperm DNA.

  • More focused on healing and regeneration.

• PN (Polynucleotide):

  • Broader category: long DNA fragments, larger molecules than PDRN.

  • Provide stronger skin scaffolding and anti-aging support.

  • Work slower than PDRN but with longer-lasting tissue remodeling.

2. Mechanism of Action

• PDRN:

  • Activates A2A adenosine receptors → boosts blood circulation & tissue healing.

  • Strong wound-healing effect → used for scars, burns, post-procedure recovery.

  • Stimulates fibroblasts → collagen production, elasticity.

• PN:

  • Improves skin elasticity, hydration, and structure by providing a scaffold for cell growth.

  • Long-term anti-aging and rejuvenation, not just healing.

  • Helps restore dermal thickness and firmness.

3. Clinical Indications

• PDRN (e.g. iReju Revital PDRN):

  • Post-acne scars, redness, and sensitive skin recovery

  • Wound healing & tissue repair after lasers/peels

  • Anti-inflammatory effects (good for rosacea-prone skin)

  • Early wrinkles, fine lines, pigmentation

• PN (e.g. iReju PN):

  • Skin laxity, sagging, and loss of firmness

  • Preventive anti-aging for younger patients

  • Improving dermal density & elasticity

  • Long-term rejuvenation and texture improvement

4. Effects

• PDRN: Faster visible improvement in healing, hydration, and texture (short-to-medium term).

• PN: More gradual improvement but longer-lasting firmness, elasticity, and anti-aging effects (medium-to-long term).

5. Treatment Focus

• PDRN → Repair & Recovery (best for damaged, sensitive, post-treatment skin)

• PN → Rejuvenation & Anti-Aging (best for firmness, elasticity, and long-term youthfulness)

✅ In short:

• Choose PDRN for healing, sensitive skin, scars, and quick recovery.

• Choose PN for firmness, elasticity, and long-term anti-aging.